It started on 18 September 2021 with the first round of the regular season and ended on 19 June 2022 with the finals.

Barça was the defending champion which lost the final series 1–3 to Real Madrid which reclaimed a record 36th Spanish title and their 14th ACB title ending a 3-year drought after their last triumph in 2019.

A total of 18 teams contested the league, including 17 sides from the 2020–21 season and one promoted from the 2020–21 LEB Oro.

In response to the COVID-19 pandemic, clubs were not allowed to use the total capacity of their arenas.

According to the progress of the pandemic, the capacity allowed each month was decided by the Government of Spain, in agreement with the Autonomous Communities.