The 2021–22 season was AFC Wimbledon's 20th year in their history and sixth consecutive season back in League One.

The season covers the period from 1 July 2021 to 30 June 2022.

AFC Wimbledon confirmed friendly matches against Brentford,[3] Kingstonian,[4] Metropolitan Police,[4] Hampton & Richmond Borough,[4] Dartford[4] and Woking[4] as part of their pre-season preparations.

Source: [citation needed] AFC Wimbledon's fixtures were announced on 24 June 2021.

[14] AFC Wimbledon were drawn into Southern Group B alongside Crystal Palace U21s, Portsmouth and Sutton United.