The 2021–22 season was the 112th season in the existence of AS Nancy Lorraine and the club's fifth consecutive season in the second division of French football.

In addition to the domestic league, Nancy participated in this season's edition of the Coupe de France.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.

Win Draw Loss Source: Soccerway Source: Ligue 2 The league fixtures were announced on 25 June 2021.