In addition to the domestic league, Saint-Étienne participated in this season's editions of the Coupe de France.

On 29 May 2022, the club's relegation to the second division was confirmed after 18 years in the top tier.

[1] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Win Draw Loss Fixtures Source: Soccerway Source: Ligue 1 The league fixtures were announced on 25 June 2021.