The 2021–22 Abilene Christian Wildcats women's basketball team represented Abilene Christian University during the 2021–22 NCAA Division I women's basketball season as members of the Western Athletic Conference.

The Wildcats, led by tenth year head coach Julie Goodenough, played their home games at the Teague Center while the Moody Coliseum was undergoing renovation construction.

This season was the Lady Cardinals' first as members of the Western Athletic Conference.

Lamar is one of four schools, all from Texas, that left the Southland Conference in July 2021 to join the WAC.

Their season ended with a 57–67 loss to sixth seeded Nicholls in the second round of the Southland women's tournament.