During the season, Arizona was invited and participated in the Roman Main Event in Paradise, Nevada.

In the postseason, Arizona defeated Stanford, and Colorado and UCLA in the championship game of the 2022 Pac-12 Conference men's basketball tournament in Paradise, Nevada, in their 8th overall.

On April 7, 2021, after 12 seasons and amid the continuing corruption scandal, the school fired head coach Sean Miller.

[1] Miller was fired on April 7, 2021, citing the program has incredibly high standards to have success on and off the court.

[4] Additionally, any players who have declared for the 2021 NBA draft—including seniors, who must opt into this year's draft—have the option to return if they make a timely withdrawal from the draft and end any pre-draft relationships with agents.

He verbally committed to Arizona on May 11, 2021, over Colorado, Cincinnati, Georgia, Marquette, San Francisco and Saint Mary's.

On June 14, 2021, Addison Arnold announced that he would join the Wildcats as a preferred walk-on during the fall as a guard.

On June 24, 2021, Benjamin Ackerley announced that he would join the Wildcats as a preferred walk-on during the fall as a guard.

[7] Former players Steve Kerr, Jason Terry, Andre Iguodala & Matt Brase all spoke.

[15][16] Arizona played the 2021 Roman Main Event in Las Vegas with Michigan, UNLV & Wichita State.