[1] On 7 November, manager Dean Smith was sacked and replaced by Steven Gerrard four days later.

[2] There were debut appearances for Leon Bailey, Emiliano Buendía, Lucas Digne, Danny Ings, Calum Chambers, Philippe Coutinho, Robin Olsen, Tim Iroegbunam, Caleb Chukwuemeka, and Aaron Ramsey.

[3] [4] On 2 July 2021, Aston Villa announced their planned pre-season friendlies for the upcoming season.

[6] A behind-closed-doors friendly against Crewe Alexandra was organised for 31 July, as a replacement for the cancelled Nottingham Forest match.

[7] On 6 August, a friendly against Serie A side Salernitana was organised to replace the cancelled Sevilla match.