In addition to the domestic league, Athletic Bilbao participated in this season's editions of the Copa del Rey and the Supercopa de España.

The first match of 2022 away to Osasuna was the 4,000th competitive fixture in the club's history (previous such milestones occurring in 1954, 1979 and 2001).

[1] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.