Conference play began in December 2021 and concluded March 8–12, 2022, with the 2022 ACC men's basketball tournament at Barclays Center in Brooklyn, New York.

Notes: Notes: The Preseason Media Poll and Preseason All-ACC teams were voted on after a tipoff event held at the Charlotte Marriott City Center in Charlotte, North Carolina on October 12, 2021.

Source:[28] This table summarizes the head-to-head results between teams in conference play.

* – Denotes overtime period To earn "consensus" status, a player must win honors based on a point system computed from the four different all-America teams.

[47] Source:[52] Armando Bacot – North Carolina Alondes Williams – Wake Forest Paolo Banchero – Duke Kameron McGusty – Miami Buddy Boeheim – Syracuse Keve Aluma – Virginia Tech Dereon Seabron – NC State Wendell Moore Jr. – Duke Blake Wesley – Notre Dame Jake LaRavia – Wake Forest Dane Goodwin – Notre Dame Mark Williams – Duke Isaiah Wong – Miami Jayden Gardner – Virginia Michael Devoe – Georgia Tech Caleb Love – North Carolina PJ Hall – Clemson John Hugley – Pittsburgh Charlie Moore – Miami Brady Manek – North Carolina Kihei Clark – Virginia AJ Griffin – Duke Paul Atkinson – Notre Dame Terquavion Smith – NC State Reece Beekman – Virginia The ACC had seven players selected in the 2022 NBA Draft.