Ayr United began the season under the management of David Hopkin who had been in charge since March of the previous season.

Hopkin would step down from his position on 9 September following a poor start to the season.

[1] He was replaced by his assistant Jim Duffy before he was also relieved of his duties by the club after just one win in eleven games.

[2] On 7 January 2022, Ayr United confirmed the appointment of Lee Bullen as their new manager.

[3] Win Draw Loss Postponed Results Notes