São Paulo won its first continental title after defeating Biguá 98–84 in the final.

[2] On 29 September 2021, FIBA announced the 12 teams from 7 countries to play in the 2021–22 BCLA season.

[4] In Argentina, San Lorenzo was crowned champions but were rejected by FIBA due to outstanding debts to players.

[5] The labels in the parentheses show how each team qualified for the place of its starting round: The draw for the regular season was held on 16 October 2021.

The Final Eight took place from 6 to 9 April 2022 at the Carioca Arena 1 in Rio de Janeiro, Brazil.