During pre-season, Valérien Ismaël departed the club as head coach and joined West Bromwich Albion.

[4] Five days later Markus Schopp was appointed head coach on a three-year contract.

[5] Barnsley revealed as part of their pre-season preparations, they would have pre-season friendly matches against AFC Fylde,[6] Rochdale,[7] Sheffield Wednesday,[8] Morecambe,[9] Watford[10] and Manchester City.

Source: [citation needed] Barnsley's league fixtures were announced on 24 June 2021.

[17] Barnsley were drawn at home to Barrow in the third round.