The season covers the period from 1 July 2021 to 30 June 2022.

During pre-season, Mark Cooper was appointed as the club's new manager on a three-year deal.

[3] Barrow confirmed they would play friendly matches against Holker Old Boys,[42] Lancaster City,[42] Spennymoor Town,[43] Birmingham City,[44] Bolton Wanderers[45] and Southport[42] as part of their pre-season schedule.

Source: [citation needed] Barrow's fixtures were announced on 24 June 2021.

[55][56] Barrow were drawn into Northern Group G alongside Accrington Stanley, Leicester City U21s and Fleetwood Town.