The season began on 5 October 2021 and ended on 15 May 2022, featuring 16 domestic champion teams.

[1] Lenovo Tenerife won its second-ever Champions League title (its last being in 2017) after defeating Baxi Manresa in the final.

[4] A total of 55 officials set to work on the 2021–22 season in Basketball Champions League:[5] The schedule of the competition will be as follows.

Clubs from Pot 1 and 2 will be seeded, and will enter directly in the semifinals stage of qualifications and will face the winners from the quarterfinals round.

The teams classified in second and third place in their respective groups of Basketball Champions League, will go on to the Play-ins.

The playoffs began on April 5, 2022 and ended with the 2022 Basketball Champions League Final Four.