In addition to the domestic league, Leverkusen participated in this season's edition of the DFB-Pokal and the UEFA Europa League.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Win Draw Loss Fixtures Source: Soccerway Source: DFB The league fixtures were announced on 25 June 2021.

[24] The draw for the group stage was held on 27 August 2021.