The Bears, members of the Big 12 Conference, played their home games at the Ferrell Center in Waco, Texas.

This was the first season in which the terms "men's" and "women's" are needed to distinguish Baylor's basketball teams.

Before this season, Baylor women's basketball had used the nickname "Lady Bears", but on September 3, 2021, the school announced that basketball, soccer, and volleyball, the last three Baylor women's sports still using "Lady", would use only "Bears" from that point forward.

The NCAA ruled that the 2020–21 season, dramatically impacted by COVID-19, would not count against the eligibility of any basketball player.

Junior guard Mathew Mayer declared for the NBA draft,[15] but withdrew his name from consideration and returned to Baylor.