As the previous season was cancelled in January 2021 due to governmental measures against COVID-19 prohibiting amateur football,[1] the division features nearly exactly teams.
In division A, champions Petegem and runners-up Ninove each won one period title, with Olsa Brakel taking the third one.
Zwevezele folded as a team and also vacated their place, meaning in the end Olsa Brakel was joined by Lokeren-Temse, Zelzate and Merelbeke.
In division B, second place finishers Eendracht Aalst were joined by Lyra-Lierse (3rd) and Cappellen (4th) who had each won a period title.
Olsa Brakel, Eendracht Aalst, Belisia and Lyra-Lierse Berlaar qualified for the VFV second round promotion play-offs.
The two other periods were won by champions RAAL La Louvière and hence 3rd and 5th placed teams Warnant and Rebecq were invited as well.
The two winners of the Promotion play-offs on the VFV side (Eendracht Aalst and Lyra-Lierse Berlaar) and Tubize-Braine, the only team with a valid license taking part in the ACFF Promotion play-offs played a final tournament together with the team that finished in 14th place in the 2021–22 Belgian National Division 1 (Mandel United).
Mandel United won 2–1 on aggregate and moves on to Final Round 2, Eendracht Aalst remains in the Belgian Division 2.