The season started on 25 November 2021 in Idre, Sweden and ended on 13 March 2022 in Ridnaun-Val Ridanna, Italy.

The defending overall champions from the 2020–21 Biathlon IBU Cup were Filip Fjeld Andersen from Norway and Vanessa Voigt from Germany.

Due to the Russian invasion of Ukraine, Russian and Belarusian biathletes are only allowed to compete under a neutral flag since the competition in Kontiolahti.

Their performances are not included in the previous classifications of their countries.

Previously, the Ukrainian national team announced the withdrawal from the biathlon competition by the end of the season.