† denotes game was played on neutral site On March 26, 2021; Purdue announced the 2021–22 season will be the last year of the "Versyp Era" at Purdue, with Katie Gearlds joining the Lady Boilers' staff and then succeeding Versyp as the head coach after the 2021–22 season.

[2] The Journal & Courier reported on August 18, 2021 that Purdue University was investigating allegations that Versyp created a "toxic and hostile environment," including verbally attacking players and bullying a member of her coaching staff.

[3] It was announced on September 16, 2021 that Versyp would be retiring and replaced by Gearlds a year earlier than originally planned.

[7] * denotes overtime period Six teams from the conference were selected to participate: Iowa (as Big Ten tournament champion), and five others at-large bids: Indiana, Maryland, Michigan, Nebraska and Ohio State.

The Big Ten conference rejected their automatic berth, the two teams qualify from at-large bids.