Ahead of the 2021–22 season the team moved from Damson Park, where they had been based since 2014, to St Andrew's, the club's main stadium.

[1] Manager Carla Ward resigned at the end of the previous campaign after only one season in charge having kept the team up with an 11th-place finish.

[4] Tony Elliott took caretaker control for the WSL game against Chelsea on 21 November before Darren Carter was appointed interim manager later that day having left a coaching role at West Bromwich Albion to take the job.

Members of the WSL since it was founded in 2011, it ended Birmingham's 20-year stint as a top-flight club having last been promoted as 2001–02 FA Women's Premier League Northern Division champions.

[6] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.