Corry Evans, Charlie Mulgrew, Amari'i Bell, Stewart Downing, Lewis Holtby, Joe Grayson, Stefan Mols, Lewis Thompson, Ben Paton, Brad Lyons and Tom White, along with scholars James Connolly, George Wyatt and Ben Pleavin, have all been informed that they will not be retained by the club when their current contracts/agreements are due to expire on June 30, 2021 The following players from the development squad Dan Pike, Sam Burn, Sam Barnes, Louie Annesley, Jalil Saadi and Sam Durrant their time with the club has been extended.

The following second-year scholars have all been offered their first professional contracts with the club Lennie Cirino, Jared Harlock, Zak Gilsenan, Alex Baker and Aidan Dowling.

[24] On 28 June 2021, Rovers announced u23 goalkeeper Joe Hilton had joined Hamilton Academical on loan until the end of the season.

[33] Also Stoke City announced the appointment of Rovers head of Academy recruitment Simon Cooper in a similar role.

[39] On 18 August 2021, Rovers announced defender Hayden Carter had signed a new contract, a three-year deal until 2024, with the option of a 12 month extension.

[41] On 23 August 2021, Rovers announced the signing of attacking midfielder Ian Poveda on loan from Leeds United until the end of the season.

[42] On 29 August 2021, Rovers announced the signing of defender Jan Paul van Hecke on loan from Brighton & Hove Albion until the end of the season.

[51] On 9 October 2021, Rovers announced u23 goalkeeper Aidan Dowling had joined Lancaster City on a month's loan until 6 November.

[53] On 16 October 2021, Rovers announced u23 forward Sam Burns had joined FC United on a month's loan until 13 November.

[54] On 22 October 2021, Rovers announced u18 forward Brandon Lonsdale had joined Lancaster City on a month's loan until 20 November.

[60] On 21 December 2021, Rovers announced defender Dan Pike had rejoined AFC Fylde on a month's loan until 16 January.

[65] On 6 January 2022, Rovers announced the signing of Irish right back James Brown from Drogheda United on a free transfer following a successful trial.

[66] On 14 January 2022, Rovers announced the signing of Dutch right back Deyovaisio Zeefuik from Hertha Berlin on loan, with a view to making the deal permanent at the end of the season.

[68] On 18 January 2022, Rovers announced the signing of Dilan Markanday from Tottenham Hotspur on a 3+1⁄2-year deal, with the option of a further 12 months, for an undisclosed fee.

[70] Rovers also announced that Totally Wicked will be the new shirt sponsor for the rest of the season after the partnership with Recoverite Compression ended with immediate effect.

[71] On 30 January 2022, Rovers announced the signing of Ryan Hedges from Aberdeen on a 3+1⁄2-year deal, with the option of a further 12 months, for an undisclosed fee.

[75] Also Rovers announced the signing of English midfielder Ryan Giles from Wolverhampton Wanderers on loan until the end of the season.

[78] On 2 March 2022, Rovers announced defender James Brown who initially joined on a 6-month deal had signed a new contract until 2024, with the option of a further 12 months.

Blackburn Rovers confirmed they would play friendlies against AFC Fylde,[100] Bradford City,[101] Leeds United[102] and Bolton Wanderers[100] as part of their pre-season preparations.