1909 and the club's seventh consecutive season in the top flight of Italian football.

In addition to the domestic league, Bologna participated in this season's edition of the Coppa Italia.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Source: Serie A The league fixtures were announced on 14 July 2021.