On April 16, 2022, the Bruins clinched a playoff spot after a 2–1 win against the Pittsburgh Penguins.
[3] They were eliminated in the first round of the playoffs by the Carolina Hurricanes, in seven games.
†Denotes player spent time with another team before joining the Bruins.
Notes: Below are the Boston Bruins' selections at the 2021 NHL Entry Draft, which was held on July 23 and 24, 2021.
It was held virtually via Video conference call from the NHL Network studio in Secaucus, New Jersey.