Olympique Khouribga and Jeunesse Soualem entered as the two promoted teams from the 2020–21 Botola 2.
Wydad AC are crowned champions of this edition with a record of 22 Botola.
Wydad AC and Raja CA drew the highest average home attendances in the 2021–22 Botola, with 45,000 and 40,087 respectively.
First goal of the season: Last goal of the season: The UMFP (Union Marocaine des Footballeurs Professionnels), in partnership with the Royal Moroccan Football Federation, organized the Night of Stars Award in its 8th edition, which celebrated the brilliants of the Botola Pro for the 2021/22 season.
Achraf Dari (Wydad AC) (Raja CA) Yahia Attiyat Allah (Wydad AC) Yassine Labhiri (MC Oudja) Mohamed Al Makahasi (Raja CA) Reda Hajhouj (Al Faisaly) Kabelo Seakanyeng (OC Khourigba)