The 2021–22 Brøndby IF season was Brøndby IF's 41st consecutive season in top-division of the Danish football league, the 32nd consecutive in Danish Superliga, and the 56th as a football club.

Besides the Superliga, the club also competed in the Danish Cup and this season's editions of the UEFA Champions League and UEFA Europa League.

It is the third season with head coach Niels Frederiksen, after he replaced caretaker manager Martin Retov during the 2019–20 campaign.

Brøndby entered this season as reigning Danish Superliga champions, having won the league title for the first time in 16 years in 2021.

[1] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.