Brighton played three pre-season friendlies, the first coming against Rangers at Ibrox on 24 July where it finished in a goalless draw, with former Albion player Connor Goldson being the main attraction of the fixture.

[1] Their second friendly fixture came a week later, away at Luton Town with former Seagulls player and coach Nathan Jones managing The Hatters.

Brighton prevailed, winning 3–1 with goals from Aaron Connolly, new summer signing Enock Mwepu and Percy Tau finding the net for the first time in an Albion shirt.

With the return of most first team players including the likes of captain Lewis Dunk and Leandro Trossard, Albion fell to a 2–0 defeat to La Liga side Getafe.

[3] Albion won their opening match of the season coming from behind to win 2–1 against Burnley at Turf Moor with goals from Neal Maupay and Alexis Mac Allister.

Summer signing Enock Mwepu made his Brighton and Premier League debut with Shane Duffy making his first Albion appearance since the 2019–20 season.

[5] Potter fielded a team of an average age of 20.5 years in the second round EFL Cup tie over Cardiff City with Jakub Moder and Andi Zeqiri grabbing their first Brighton goals in the 2–0 away win.

[8] Brighton's second loss of the Premier League season came on 23 October, in their ninth game, losing 4–1 at home with Manchester City winning comfortably, scoring their first three goals in the space of 18 minutes.

[9] Four days later, Brighton were knocked of the EFL Cup, losing away to Leicester City on penalties after a 2–2 draw in which Mwepu scored his first goal for the club.

[13] Albion's Premier League fixture with Tottenham Hotspur set to be played on 12 December was postponed three days prior to the match with Spurs having high numbers of Covid-19 cases.

[18] Brighton beat West Brom in the third round of the FA Cup on 8 January 2022, with Odel Offiah making his first start for the club in the eventual 2–1 after extra-time away victory.

[19] In the reverse fixture against Palace on 15 January, Pascal Groß had a penalty saved from Eagles keeper Jack Butland to deny Brighton of going 1–0 up.

He was originally shown a yellow card by referee Peter Bankes, however, Bankes went to VAR and deemed Dunk to have denied Anthony Elanga a run on goal [22][23] After six straight defeats Brighton ended the run with a somewhat disappointing draw with Norwich City on 2 April, finishing 0–0 at home with a Neal Maupay penalty being stuck over the bar.

[60] • Andi Zeqiri moved to Bundesliga side FC Augsburg on 30 August where he will spend the season on loan at the club.