[1] The competition began on 4 September 2021 with the preliminary round and finished with the final on 15 May 2022.

They reached the final for 3rd consecutive time, but lost to Levski Sofia, who won the cup for a record 26th time and also qualified for the second qualifying round of the 2022–23 UEFA Europa Conference League.

The following 47 teams qualified for the competition:[3] Arda Kardzhali Beroe Stara Zagora Botev Plovdiv Botev Vratsa CSKA 1948 Sofia CSKA Sofia Cherno More Varna Levski Sofia Lokomotiv Plovdiv Lokomotiv Sofia Ludogorets Razgrad Pirin Blagoevgrad Slavia Sofia Tsarsko Selo Sofia Dobrudzha Dobrich Etar Veliko Tarnovo Hebar Pazardzhik Levski Lom Litex Lovech Marek Dupnitsa Maritsa Plovdiv Minyor Pernik Montana Neftochimic Burgas Septemvri Simitli Septemvri Sofia Sozopol Spartak Varna Sportist Svoge Strumska Slava Radomir Yantra Gabrovo from North-East zone: from North-West zone: from South-West zone: from South-East zone: The draw was conducted on 27 August 2021.

[5] In this stage participated 16 winners from the regional amateur competitions and 17 non-reserve teams from Second League.

[20] Contrary to the generally accepted regulations in European football, the away goals rule will apply.