The season covered the period from 1 July 2021 to 30 June 2022.

Burnley suffered poor form throughout their season and in mid-April, with the club in the relegation zone, manager Sean Dyche was sacked after nearly 10 years in charge.

Under-23 manager Mike Jackson was appointed as caretaker, and results did initially pick up - however, a run of one point from the team's last four games, including a last-day 2–1 home defeat to Newcastle United, saw Burnley end the season in 18th position and condemn them to relegation to the EFL Championship for the 2022–23 season.

After the match against Liverpool on 21 August 2021 (2–0 loss), Burnley broke the Premier League record for the most consecutive games without a red card, after having no player sent off in 95 matches.

[1] This run ended at 119 games when Nathan Collins received a red card during a match against Brentford on 12 March 2022.