The season covers the period from 1 July 2021 to 30 June 2022.

Note: Flags indicate national team as has been defined under FIFA eligibility rules.

Source: [citation needed] Burton Albion's fixtures were revealed on 24 June 2021.

[9] Burton Albion were drawn at home to Oxford United in the first round.

[10][11] Burton were drawn into Group C in the Southern section, alongside Milton Keynes Dons and Wycombe Wanderers.