Wydad Casablanca won their 3rd title with a 2–0 win against the defending champions, Al Ahly, in the final at Stade Mohammed V in Casablanca, Morocco, which hosted a second consecutive final.

Notes: The schedule for this season's edtition of the tournament were as follows: The draw for the qualifying rounds was held on 13 August 2021 at the CAF headquarters in Cairo, Egypt.

If the aggregate score is tied after the second leg, the away goals rule was applied, and if still tied, extra time won't be played, and the penalty shoot-out was used to determine the winner (Regulations III.

The winners and runners-up of each group advanced to the quarter-finals of the knockout stage.

The mechanism of the draws for each round was as follows: The bracket was decided after the draw for the knockout stage (quarter-finals and semi-finals), which was held on 5 April 2022, 13:00 GMT (15:00 local time, UTC+2), at the CAF headquarters in Cairo, Egypt.