The final was won by RS Berkane of Morocco 5–4 on penalties after a 1–1 draw after 120 minutes of regulation time against Orlando Pirates and RS Berkane at the Godswill Akpabio International Stadium in Uyo, Nigeria, capturing their second title in the process.

[TAN] Both the winners Simba SC and runner-ups Young Africans S.C. of the 2020–21 Tanzania FA Cup qualified for the 2021-22 CAF Champions League resulting in the slot usually allocated to the winner or runner-up of the Tanzania FA Cup to be awarded to the fourth placed team in the 2020–21 Tanzanian Premier League.

The winners and runners-up of each group advanced to the quarter-finals of the knockout stage.

The mechanism of the draws for each round was as follows: The bracket was decided after the draw for the knockout stage (quarter-finals and semi-finals), which was held on 5 April 2022, 13:00 GMT (15:00 local time, UTC+2), at the CAF headquarters in Cairo, Egypt.

[15] The final was played on 20 May 2022 at Godswill Akpabio International Stadium, Uyo.