The 2021–22 CEV Champions League was the 63rd edition of the highest level European volleyball club competition organised by the European Volleyball Confederation.

[1] Drawing of Lots was held on 24 September 2021 in Ljubljana.

[3]

Sir Sicoma Monini Perugia Jastrzębski Węgiel Dynamo Moscow Berlin Recycling Volleys Cucine Lube Civitanova Itas Trentino ZAKSA Kędzierzyn-Koźle Zenit Saint Petersburg