The 2021–22 CEV Cup was the 50th edition of the second most important European volleyball club competition organised by the European Volleyball Confederation.

[1] The drawing of lots took place on 25 June 2021 in Luxembourg City.

[2] Qualification round (Home and away matches): Main phase (Home and away matches): Final phase (Home and away matches): Aggregate score is counted as follows: 3 points for 3–0 or 3–1 win, 2 points for 3–2 win, 1 point for 2–3 loss.

In case the teams are tied after two legs, a Golden Set is played immediately at the completion of the second leg.