The 2021–22 CEV Women's Champions League was the 62nd edition of the highest level European volleyball club competition organised by the European Volleyball Confederation.

[1] Drawing of Lots was held on 24 September 2021 in Ljubljana.

[3] A. Carraro Imoco Conegliano VakifBank Istanbul Fenerbahçe Opet Istanbul Dinamo Moscow Developres SkyRes Rzeszów Lokomotiv Kaliningrad Dinamo-AK Bars Kazan Vero Volley Monza