The 2021–22 season was Fotbal Club CFR 1907 Cluj's 26th consecutive season in the Liga I and 114th year in existence as a football club.

In addition to the domestic league, CFR Cluj participated in this season's editions of the Cupa României, the Supercupa României, the UEFA Champions League, the UEFA Europa League and the UEFA Europa Conference League.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Source: [2] Source: Competitions CFR Cluj, as Liga I winners in the previous season, played against Universitatea Craiova in the 2021 Supercupa României, who themselves won the Cupa României.

The draw for the group stage was held on 27 August 2021, 13:30 CEST (14:30 TRT), in Istanbul, Turkey.