The 2021–22 CSA One-Day Cup was a List A cricket competition that took place in South Africa in March and April 2022.
[3] Domestic cricketing reforms were introduced in 2020 that discontinued the six franchise team format and announced a return to the more traditional provincial based system.
Fifteen teams, split over the two divisions, competed in the one-day tournament.
[9] Lions won the Division One title,[10] beating Titans by three wickets, with Reeza Hendricks scoring 157 runs.
[11] In the Division Two final, KwaZulu-Natal Inland beat Northern Cape by five wickets to win the match.