On 8 May 2022, Benfica beat Sporting CP at home by 3–1 and became champions for the second time in their history.
16 teams contested the Campeonato Nacional de Futebol Feminino in 2021–22.
[4] In the first stage, the 16 clubs will be divided in two series (North and South) of 8 teams, according to geographic criteria.
On the championship group, all eight teams play against each other in a home-and-away double round-robin system, to decide the champions.
Only the winner guarantees a place in 2022–23 Campeonato Nacional de Futebol Feminino.