2021–22 Campionato Sammarinese di Calcio

The 2021–22 Campionato Sammarinese di Calcio was the 37th season of league competition in San Marino, in which the country's top 15 amateur football teams competed.

[2] Runners-up, Tre Penne qualified for a place in the 2022–23 UEFA Europa Conference League.

La Fiorita won their sixth title by defeating Tre Penne in the final, 2–0.

The regular season was contested by fifteen teams who played each other twice.

La Fiorita qualified as the winner to the 2022–23 UEFA Champions League and Tre Penne as the loser to the 2022–23 UEFA Europa Conference League.