The 2021–22 Canisius Golden Griffins men's basketball team represented Canisius College in the 2021–22 NCAA Division I men's basketball season.

The Golden Griffins, led by sixth-year head coach Reggie Witherspoon, played their home games at the Koessler Athletic Center in Buffalo, New York as members of the Metro Atlantic Athletic Conference.

The Golden Griffins finished the 2020–21 season 7–6, 7–5 in MAAC play to finish in a tie for fifth place.

6 seed in the MAAC tournament, they were upset in the first round by No.

[1] Roster Last update: November 30, 2021 Sources[2]