The 2021–22 season is the 17th in the history of the Central Coast Mariners Football Club.

This is the Central Coast Mariners' 17th season in the A-League.

In addition to the domestic league, Central Coast also participated in the FFA Cup.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Win Draw Loss Cancelled or postponed Last updated: 20 February 2022 Source: Competitions Numbers in parentheses denote appearances as substitute.