The 2021–22 Championnat National 2 was the 24th season of the fourth tier in the French football league system in its current format.
This season the competition was contested by 64 clubs split geographically across four groups of 16 teams.
Three opening day games in Group C were postponed due to COVID-19 cases at Saint-Priest, Martigues and Aubagne.
Versailles, Martigues, Paris 13 Atletico and Le Puy were champions of each group, and were promoted to 2022–23 Championnat National, subject to the usual ratification by the FFF and DNCG.
On 14 June 2022, the DNCG announced that Béziers were to be relegated to Championnat National 3 for the 2022–23 season, due to financial mismanagement.