The regular season started on 25 September 2021 and ended on 10 May 2022.
[1] US Monastir won its seventh league title; it was its fourth straight victorious season.
This season featured 10 teams, with SS Sfaxien and US Ansar joining the league as newcomers.
In the play-offs, the six highest ranked team from the regular season play against each other.
Numbers in brackets denote the team's seed.