The 2021–22 College of Charleston Cougars men's basketball team represented the College of Charleston in the 2021–22 NCAA Division I men's basketball season.

The Cougars, led by first-year head coach Pat Kelsey, played their home games at the TD Arena in Charleston, South Carolina as members of the Colonial Athletic Association.

They defeated Hofstra in the quarterfinals of the CAA tournament before losing to UNC Wilmington in the semifinals.

In a season limited due to the ongoing COVID-19 pandemic, the Cougars finished the 2020–21 season 9–10, 6–4 CAA play to finish in third place.

They lost in the quarterfinals of the CAA tournament to Drexel.