The 2021–22 Charleston Southern Buccaneers men's basketball team represented Charleston Southern University in the 2021–22 NCAA Division I men's basketball season.

The Buccaneers, led by 17th-year head coach Barclay Radebaugh, played their home games at the Buccaneer Field House in North Charleston, South Carolina as members of the Big South Conference.

12 seed in the Big South tournament, they defeated UNC Asheville in the first round before losing to USC Upstate in the quarterfinals.

In a season limited due to the ongoing COVID-19 pandemic, the Buccaneers finished the 2020–21 season 3–18, 2–15 in Big South play to finish in last place, before cancelling the remainder of their season on February 23, 2021 due to COVID-19 issues in the program.

[2] Roster Last update: December 20, 2021 Sources[3][4]