Along with the league, the club also competed in the FA Cup, the EFL Cup and the EFL Trophy.

The season covers the period from 1 July 2021 to 30 June 2022.

Cheltenham Town announced they would play friendlies against Cinderford Town,[1] Evesham United,[1] Birmingham City,[2] Kidderminster Harriers,[3] Coventry City,[4] Hungerford Town,[5] Hereford[3] and Walsall[6] as part of their pre-season preparations.

Source: [citation needed] Cheltenham Town's fixtures were announced on 24 June 2021.

[16][17] Cheltenham were drawn into Group E in the Southern section, alongside Bristol Rovers, Chelsea U21s and Exeter City.