The Cougars were led by first-year head coach Gerald Gillion.

They played their home games at the Emil and Patricia Jones Convocation Center as members of the Western Athletic Conference.

This was Chicago State's final season in the WAC, and a new conference has yet to be officially announced.

[3] On July 19, the school named Samford assistant Gerald Gillion the new head coach.

[4] Roster Last update: February 10, 2022 Source[5] 2021–22 Chicago State Cougars women's basketball team