The 2021–22 Cleveland State Vikings men's basketball team represented Cleveland State University in the 2021–22 NCAA Division I men's basketball season.

The Vikings, led by third-year head coach Dennis Gates, played their home games at the Wolstein Center in Cleveland, Ohio as members of the Horizon League.

1 seed in the Horizon League tournament, they defeated Robert Morris in the quarterfinals before losing to Wright State in the semifinals.

1 seed in the Horizon League tournament, they defeated Purdue Fort Wayne,[1] Milwaukee,[2] and Oakland to win the tournament championship.

15 seed in the Midwest Region, they lost to Houston in the first round.