The team will participate in the Liga MX.

Source: Club América Players and squad numbers last updated on 26 January 2022.

[1]Note: Flags indicate national team as has been defined under FIFA eligibility rules.

Players may hold more than one non-FIFA nationality.

[31] Last updated: 22 May 2022 Source: Competitions Source: Match reports Source: Match reports The 2021 CONCACAF Champions League began during the 2020–21 Liga MX season.