The 2021–22 Colorado Buffaloes women's basketball team represented the University of Colorado Boulder during the 2021–22 NCAA Division I women's basketball season.

The Buffaloes, led by sixth year head coach JR Payne, played their home games at the CU Events Center and competed as members of the Pac-12 Conference.

The Buffaloes were the last undefeated DI women's college basketball in the 2021-22 season, losing their first game to #2 Stanford on January 14, 2022.

As the sixth seed in the Pac-12 women's tournament they lost to Washington in the First Round.

They received an invitation to the WNIT where they defeated Louisiana in the first round and Nebraska in the second round before losing to Ole Miss in the quarterfinals.