The 2021–22 season was Como 1907's first season back in second division of the Italian football league, the Serie B, and the 115th as a football club.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.
Players may hold more than one non-FIFA nationality.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.
Win Draw Loss Fixtures Source: Soccerway Source: Serie B The league fixtures were announced on 24 July 2021.